Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50380025' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50380025
(CHEMBL2012610)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(COc2ccccc2)s1 |r,wU:7.10,wD:4.3,(42.73,-17.37,;41.19,-17.39,;40.44,-18.73,;40.41,-16.07,;38.87,-16.09,;38.08,-14.76,;36.54,-14.78,;35.79,-16.13,;36.57,-17.45,;38.11,-17.43,;34.25,-16.15,;33.47,-14.83,;31.93,-14.85,;31.18,-16.18,;31.96,-17.5,;33.5,-17.49,;29.64,-16.2,;28.86,-14.87,;28.89,-17.54,;27.35,-17.56,;26.43,-16.32,;24.97,-16.82,;24.98,-18.36,;23.64,-19.11,;22.32,-18.33,;20.97,-19.08,;19.65,-18.29,;18.31,-19.05,;18.29,-20.59,;19.63,-21.37,;20.96,-20.62,;26.45,-18.82,)| Show InChI InChI=1S/C24H25N3O4S/c28-22(29)14-16-6-8-17(9-7-16)18-10-12-19(13-11-18)23(30)25-24-27-26-21(32-24)15-31-20-4-2-1-3-5-20/h1-5,10-13,16-17H,6-9,14-15H2,(H,28,29)(H,25,27,30)/t16-,17- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DGAT1 expressed in baculovirus infected Sf9 cells after 60 mins by scintillation counting method |
Bioorg Med Chem Lett 22: 2497-502 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.006 BindingDB Entry DOI: 10.7270/Q2VQ33PZ |
More data for this Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50380025
(CHEMBL2012610)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(COc2ccccc2)s1 |r,wU:7.10,wD:4.3,(42.73,-17.37,;41.19,-17.39,;40.44,-18.73,;40.41,-16.07,;38.87,-16.09,;38.08,-14.76,;36.54,-14.78,;35.79,-16.13,;36.57,-17.45,;38.11,-17.43,;34.25,-16.15,;33.47,-14.83,;31.93,-14.85,;31.18,-16.18,;31.96,-17.5,;33.5,-17.49,;29.64,-16.2,;28.86,-14.87,;28.89,-17.54,;27.35,-17.56,;26.43,-16.32,;24.97,-16.82,;24.98,-18.36,;23.64,-19.11,;22.32,-18.33,;20.97,-19.08,;19.65,-18.29,;18.31,-19.05,;18.29,-20.59,;19.63,-21.37,;20.96,-20.62,;26.45,-18.82,)| Show InChI InChI=1S/C24H25N3O4S/c28-22(29)14-16-6-8-17(9-7-16)18-10-12-19(13-11-18)23(30)25-24-27-26-21(32-24)15-31-20-4-2-1-3-5-20/h1-5,10-13,16-17H,6-9,14-15H2,(H,28,29)(H,25,27,30)/t16-,17- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis R&D
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DGAT1 in Chang cells using [14C]-glycerol as substrate assessed as decrease in triglycerides synthesis after 6 hrs by... |
Bioorg Med Chem Lett 22: 2497-502 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.006 BindingDB Entry DOI: 10.7270/Q2VQ33PZ |
More data for this Ligand-Target Pair | |