Found 3 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50437379' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50437379
(CHEMBL2408627)Show SMILES Cc1ccc2[nH]c(nc2n1)-c1ccc(nc1)-c1ccc(O[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |r,wU:21.23,wD:24.30,(23.65,-38.67,;24.99,-39.43,;24.99,-40.97,;26.32,-41.74,;27.65,-40.98,;29.12,-41.45,;30.02,-40.21,;29.12,-38.96,;27.65,-39.43,;26.32,-38.66,;31.56,-40.2,;32.32,-38.88,;33.86,-38.87,;34.64,-40.21,;33.87,-41.54,;32.33,-41.54,;36.17,-40.21,;36.94,-38.88,;38.47,-38.87,;39.25,-40.21,;40.79,-40.2,;41.57,-41.53,;43.1,-41.51,;43.87,-42.85,;43.1,-44.19,;41.56,-44.19,;40.79,-42.86,;43.87,-45.53,;43.1,-46.86,;45.41,-45.53,;38.48,-41.54,;36.94,-41.54,)| Show InChI InChI=1S/C24H23N5O3/c1-14-2-9-20-23(27-14)29-22(28-20)17-5-10-19(25-13-17)16-6-11-21(26-12-16)32-18-7-3-15(4-8-18)24(30)31/h2,5-6,9-13,15,18H,3-4,7-8H2,1H3,(H,30,31)(H,27,28,29)/t15-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 |
ACS Med Chem Lett 4: 773-8 (2013)
Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50437379
(CHEMBL2408627)Show SMILES Cc1ccc2[nH]c(nc2n1)-c1ccc(nc1)-c1ccc(O[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |r,wU:21.23,wD:24.30,(23.65,-38.67,;24.99,-39.43,;24.99,-40.97,;26.32,-41.74,;27.65,-40.98,;29.12,-41.45,;30.02,-40.21,;29.12,-38.96,;27.65,-39.43,;26.32,-38.66,;31.56,-40.2,;32.32,-38.88,;33.86,-38.87,;34.64,-40.21,;33.87,-41.54,;32.33,-41.54,;36.17,-40.21,;36.94,-38.88,;38.47,-38.87,;39.25,-40.21,;40.79,-40.2,;41.57,-41.53,;43.1,-41.51,;43.87,-42.85,;43.1,-44.19,;41.56,-44.19,;40.79,-42.86,;43.87,-45.53,;43.1,-46.86,;45.41,-45.53,;38.48,-41.54,;36.94,-41.54,)| Show InChI InChI=1S/C24H23N5O3/c1-14-2-9-20-23(27-14)29-22(28-20)17-5-10-19(25-13-17)16-6-11-21(26-12-16)32-18-7-3-15(4-8-18)24(30)31/h2,5-6,9-13,15,18H,3-4,7-8H2,1H3,(H,30,31)(H,27,28,29)/t15-,18- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 |
ACS Med Chem Lett 4: 773-8 (2013)
Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50437379
(CHEMBL2408627)Show SMILES Cc1ccc2[nH]c(nc2n1)-c1ccc(nc1)-c1ccc(O[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |r,wU:21.23,wD:24.30,(23.65,-38.67,;24.99,-39.43,;24.99,-40.97,;26.32,-41.74,;27.65,-40.98,;29.12,-41.45,;30.02,-40.21,;29.12,-38.96,;27.65,-39.43,;26.32,-38.66,;31.56,-40.2,;32.32,-38.88,;33.86,-38.87,;34.64,-40.21,;33.87,-41.54,;32.33,-41.54,;36.17,-40.21,;36.94,-38.88,;38.47,-38.87,;39.25,-40.21,;40.79,-40.2,;41.57,-41.53,;43.1,-41.51,;43.87,-42.85,;43.1,-44.19,;41.56,-44.19,;40.79,-42.86,;43.87,-45.53,;43.1,-46.86,;45.41,-45.53,;38.48,-41.54,;36.94,-41.54,)| Show InChI InChI=1S/C24H23N5O3/c1-14-2-9-20-23(27-14)29-22(28-20)17-5-10-19(25-13-17)16-6-11-21(26-12-16)32-18-7-3-15(4-8-18)24(30)31/h2,5-6,9-13,15,18H,3-4,7-8H2,1H3,(H,30,31)(H,27,28,29)/t15-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human ACAT1 |
ACS Med Chem Lett 4: 773-8 (2013)
Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28 |
More data for this
Ligand-Target Pair | |
Search and Browse
