Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50438705' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438705
(CHEMBL2414698)Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](Cc4nnn[nH]4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(23.78,-52.15,;23.8,-53.69,;22.46,-54.48,;22.48,-56.03,;23.83,-56.79,;25.16,-56,;26.38,-56.96,;27.89,-56.59,;28.55,-55.2,;27.85,-53.8,;28.81,-52.58,;28.25,-51.14,;29.2,-49.94,;30.71,-50.17,;31.28,-51.59,;30.33,-52.79,;31.69,-48.94,;31.11,-47.48,;32.06,-46.28,;33.57,-46.51,;34.55,-45.27,;36.06,-45.49,;37.13,-44.36,;38.53,-45.04,;38.31,-46.57,;36.79,-46.84,;34.13,-47.92,;33.18,-49.12,;26.35,-53.47,;25.99,-51.97,;25.15,-54.45,)| Show InChI InChI=1S/C21H24N8O2/c22-19-18-20(24-12-23-19)31-10-9-29(21(18)30)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17-25-27-28-26-17/h5-8,12-14H,1-4,9-11H2,(H2,22,23,24)(H,25,26,27,28)/t13-,14- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045 BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438705
(CHEMBL2414698)Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](Cc4nnn[nH]4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(23.78,-52.15,;23.8,-53.69,;22.46,-54.48,;22.48,-56.03,;23.83,-56.79,;25.16,-56,;26.38,-56.96,;27.89,-56.59,;28.55,-55.2,;27.85,-53.8,;28.81,-52.58,;28.25,-51.14,;29.2,-49.94,;30.71,-50.17,;31.28,-51.59,;30.33,-52.79,;31.69,-48.94,;31.11,-47.48,;32.06,-46.28,;33.57,-46.51,;34.55,-45.27,;36.06,-45.49,;37.13,-44.36,;38.53,-45.04,;38.31,-46.57,;36.79,-46.84,;34.13,-47.92,;33.18,-49.12,;26.35,-53.47,;25.99,-51.97,;25.15,-54.45,)| Show InChI InChI=1S/C21H24N8O2/c22-19-18-20(24-12-23-19)31-10-9-29(21(18)30)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17-25-27-28-26-17/h5-8,12-14H,1-4,9-11H2,(H2,22,23,24)(H,25,26,27,28)/t13-,14- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 774 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi... |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045 BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this Ligand-Target Pair | |