Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50438729' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438729
(CHEMBL2414651)Show SMILES CC(C)[C@H](CO)NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:3.5,13.16,wD:10.9,(35.51,-41.58,;36.49,-40.39,;38.01,-40.66,;35.96,-38.95,;36.95,-37.77,;38.47,-38.03,;34.45,-38.69,;33.46,-39.89,;34,-41.32,;31.94,-39.63,;30.96,-40.82,;29.46,-40.6,;28.48,-41.77,;29.01,-43.2,;30.52,-43.46,;31.49,-42.28,;28.02,-44.41,;28.56,-45.87,;27.59,-47.05,;26.09,-46.8,;25.56,-45.37,;26.53,-44.19,;25.09,-48,;25.76,-49.42,;25.08,-50.8,;23.56,-51.13,;22.37,-50.14,;21.03,-50.91,;19.69,-50.13,;19.71,-48.57,;21.05,-47.82,;21.07,-46.28,;22.38,-48.61,;23.6,-47.66,;23.28,-46.14,)| Show InChI InChI=1S/C26H35N5O4/c1-16(2)21(14-32)30-22(33)13-17-3-5-18(6-4-17)19-7-9-20(10-8-19)31-11-12-35-25-23(26(31)34)24(27)28-15-29-25/h7-10,15-18,21,32H,3-6,11-14H2,1-2H3,(H,30,33)(H2,27,28,29)/t17-,18-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi... |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438729
(CHEMBL2414651)Show SMILES CC(C)[C@H](CO)NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:3.5,13.16,wD:10.9,(35.51,-41.58,;36.49,-40.39,;38.01,-40.66,;35.96,-38.95,;36.95,-37.77,;38.47,-38.03,;34.45,-38.69,;33.46,-39.89,;34,-41.32,;31.94,-39.63,;30.96,-40.82,;29.46,-40.6,;28.48,-41.77,;29.01,-43.2,;30.52,-43.46,;31.49,-42.28,;28.02,-44.41,;28.56,-45.87,;27.59,-47.05,;26.09,-46.8,;25.56,-45.37,;26.53,-44.19,;25.09,-48,;25.76,-49.42,;25.08,-50.8,;23.56,-51.13,;22.37,-50.14,;21.03,-50.91,;19.69,-50.13,;19.71,-48.57,;21.05,-47.82,;21.07,-46.28,;22.38,-48.61,;23.6,-47.66,;23.28,-46.14,)| Show InChI InChI=1S/C26H35N5O4/c1-16(2)21(14-32)30-22(33)13-17-3-5-18(6-4-17)19-7-9-20(10-8-19)31-11-12-35-25-23(26(31)34)24(27)28-15-29-25/h7-10,15-18,21,32H,3-6,11-14H2,1-2H3,(H,30,33)(H2,27,28,29)/t17-,18-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
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