Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50438734' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438734
(CHEMBL2414751)Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)NC4CCCC4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(18.45,-49.67,;18.43,-51.23,;17.08,-51.99,;17.06,-53.55,;18.41,-54.34,;19.76,-53.56,;20.96,-54.56,;22.49,-54.23,;23.17,-52.83,;22.49,-51.41,;23.5,-50.2,;25.01,-50.45,;25.99,-49.27,;25.44,-47.79,;23.94,-47.58,;22.96,-48.76,;26.44,-46.58,;25.91,-45.15,;26.89,-43.96,;28.39,-44.18,;29.39,-42.99,;30.92,-43.25,;31.46,-44.69,;31.91,-42.04,;33.43,-42.3,;34.11,-43.68,;35.64,-43.46,;35.9,-41.94,;34.54,-41.22,;28.94,-45.65,;27.95,-46.84,;20.99,-51.06,;20.67,-49.54,;19.77,-52.02,)| Show InChI InChI=1S/C26H33N5O3/c27-24-23-25(29-16-28-24)34-14-13-31(26(23)33)21-11-9-19(10-12-21)18-7-5-17(6-8-18)15-22(32)30-20-3-1-2-4-20/h9-12,16-18,20H,1-8,13-15H2,(H,30,32)(H2,27,28,29)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi... |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438734
(CHEMBL2414751)Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)NC4CCCC4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(18.45,-49.67,;18.43,-51.23,;17.08,-51.99,;17.06,-53.55,;18.41,-54.34,;19.76,-53.56,;20.96,-54.56,;22.49,-54.23,;23.17,-52.83,;22.49,-51.41,;23.5,-50.2,;25.01,-50.45,;25.99,-49.27,;25.44,-47.79,;23.94,-47.58,;22.96,-48.76,;26.44,-46.58,;25.91,-45.15,;26.89,-43.96,;28.39,-44.18,;29.39,-42.99,;30.92,-43.25,;31.46,-44.69,;31.91,-42.04,;33.43,-42.3,;34.11,-43.68,;35.64,-43.46,;35.9,-41.94,;34.54,-41.22,;28.94,-45.65,;27.95,-46.84,;20.99,-51.06,;20.67,-49.54,;19.77,-52.02,)| Show InChI InChI=1S/C26H33N5O3/c27-24-23-25(29-16-28-24)34-14-13-31(26(23)33)21-11-9-19(10-12-21)18-7-5-17(6-8-18)15-22(32)30-20-3-1-2-4-20/h9-12,16-18,20H,1-8,13-15H2,(H,30,32)(H2,27,28,29)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this
Ligand-Target Pair | |
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