Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50438737' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438737
(CHEMBL2414668)Show SMILES CC(C)(O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:8.11,wD:5.4,(35.63,-43.7,;35.14,-42.24,;36.17,-41.09,;36.63,-42.63,;33.64,-41.93,;32.61,-43.1,;31.12,-42.8,;30.1,-43.94,;30.6,-45.42,;32.08,-45.69,;33.1,-44.55,;29.56,-46.59,;28.07,-46.29,;27.05,-47.44,;27.54,-48.91,;29.04,-49.19,;30.05,-48.04,;26.52,-50.06,;27.13,-51.49,;26.4,-52.84,;24.87,-53.12,;23.72,-52.1,;22.34,-52.82,;21.04,-51.99,;21.11,-50.45,;22.47,-49.73,;22.54,-48.19,;23.78,-50.56,;25.03,-49.66,;24.75,-48.13,)| Show InChI InChI=1S/C23H30N4O3/c1-23(2,29)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)27-11-12-30-21-19(22(27)28)20(24)25-14-26-21/h7-10,14-16,29H,3-6,11-13H2,1-2H3,(H2,24,25,26)/t15-,16- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045 BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50438737
(CHEMBL2414668)Show SMILES CC(C)(O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:8.11,wD:5.4,(35.63,-43.7,;35.14,-42.24,;36.17,-41.09,;36.63,-42.63,;33.64,-41.93,;32.61,-43.1,;31.12,-42.8,;30.1,-43.94,;30.6,-45.42,;32.08,-45.69,;33.1,-44.55,;29.56,-46.59,;28.07,-46.29,;27.05,-47.44,;27.54,-48.91,;29.04,-49.19,;30.05,-48.04,;26.52,-50.06,;27.13,-51.49,;26.4,-52.84,;24.87,-53.12,;23.72,-52.1,;22.34,-52.82,;21.04,-51.99,;21.11,-50.45,;22.47,-49.73,;22.54,-48.19,;23.78,-50.56,;25.03,-49.66,;24.75,-48.13,)| Show InChI InChI=1S/C23H30N4O3/c1-23(2,29)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)27-11-12-30-21-19(22(27)28)20(24)25-14-26-21/h7-10,14-16,29H,3-6,11-13H2,1-2H3,(H2,24,25,26)/t15-,16- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi... |
Bioorg Med Chem 21: 5081-97 (2013)
Article DOI: 10.1016/j.bmc.2013.06.045 BindingDB Entry DOI: 10.7270/Q26111RG |
More data for this Ligand-Target Pair | |