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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM50499291'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM50499291
PNG
(CHEMBL3735666)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@H]2c2ccccc2)c2cnccc12 |r|
Show InChI InChI=1S/C27H21F3N2O2/c28-27(29,30)34-20-8-4-7-18(13-20)21-10-9-19(25-16-31-12-11-22(21)25)15-32-26(33)24-14-23(24)17-5-2-1-3-6-17/h1-13,16,23-24H,14-15H2,(H,32,33)/t23-,24+/m0/s1
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Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Merck & Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrate

J Med Chem 58: 9345-53 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01345
BindingDB Entry DOI: 10.7270/Q28W3H9F
More data for this
Ligand-Target Pair