Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Dihydroorotate dehydrogenase (quinone), mitochondrial' and Ligand = 'BDBM155413'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155413 (US9006454, I25) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1ccc(cc1F)-c1ccccc1F Show InChI InChI=1S/C21H14F2N2O2/c1-11-8-15(21(26)27)19-18(9-11)24-20(25-19)14-7-6-12(10-17(14)23)13-4-2-3-5-16(13)22/h2-10H,1H3,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
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