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Found 1 hit Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 8' and Ligand = 'BDBM50350173'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50350173
PNG
(CHEMBL1814743)
Show SMILES N[C@@H](CC(=O)N1CCN(Cc2ccc(cc2)-c2ccccc2C#N)CC1)C(=O)N1Cc2ccccc2C1 |r|
Show InChI InChI=1S/C30H31N5O2/c31-18-24-5-3-4-8-27(24)23-11-9-22(10-12-23)19-33-13-15-34(16-14-33)29(36)17-28(32)30(37)35-20-25-6-1-2-7-26(25)21-35/h1-12,28H,13-17,19-21,32H2/t28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 141n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...

J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair