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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 8' and Ligand = 'BDBM50350184'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50350184
PNG
(CHEMBL1814755)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1 |r|
Show InChI InChI=1S/C30H30F2N4O3/c31-23-11-7-19(8-12-23)28(20-9-13-24(32)14-10-20)34-29(38)26-6-3-15-36(26)27(37)16-25(33)30(39)35-17-21-4-1-2-5-22(21)18-35/h1-2,4-5,7-14,25-26,28H,3,6,15-18,33H2,(H,34,38)/t25-,26-/m0/s1
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Similars
Article
PubMed
n/an/a 910n/an/an/an/an/an/a



University of Antwerp (UA)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...

J Med Chem 54: 5737-46 (2011)


Article DOI: 10.1021/jm200383j
BindingDB Entry DOI: 10.7270/Q2G73F37
More data for this
Ligand-Target Pair