Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B' and Ligand = 'BDBM292982'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM292982 (US10105367, Example 268 | US10376514, Example 268) Show SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(O)CN2C[C@H](C)O[C@H](C)C2)cc1 |r| Show InChI InChI=1S/C24H28N6O4/c1-15-10-28(11-16(2)34-15)13-21(31)18-8-20-22(25-9-18)29(24(32)30-23(20)26-14-27-30)12-17-4-6-19(33-3)7-5-17/h4-9,14-16,21,31H,10-13H2,1-3H3/t15-,16+,21?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...				US Patent US10376514 (2019) BindingDB Entry DOI: 10.7270/Q2ST7S6W
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM292982 (US10105367, Example 268 | US10376514, Example 268) Show SMILES COc1ccc(Cn2c3ncc(cc3c3ncnn3c2=O)C(O)CN2C[C@H](C)O[C@H](C)C2)cc1 |r| Show InChI InChI=1S/C24H28N6O4/c1-15-10-28(11-16(2)34-15)13-21(31)18-8-20-22(25-9-18)29(24(32)30-23(20)26-14-27-30)12-17-4-6-19(33-3)7-5-17/h4-9,14-16,21,31H,10-13H2,1-3H3/t15-,16+,21?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
DART NEUROSCIENCE (CAYMAN) LTD. US Patent					Assay Description PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...				US Patent US10105367 (2018) BindingDB Entry DOI: 10.7270/Q2KW5J3Q
					More data for this Ligand-Target Pair