Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM135147' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM135147
(US8846657, 3.39)Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)C(O)=O)N2CCC[C@H]2C(F)(F)F)CC1 |r,wU:4.4,wD:1.0,29.33,(6.57,-3.2,;5.09,-2.81,;4.69,-1.32,;3.2,-.92,;2.11,-2.01,;.62,-1.61,;.23,-.12,;1.13,1.12,;.23,2.37,;-1.24,1.89,;-2.57,2.66,;-3.91,1.89,;-3.91,.35,;-2.57,-.42,;-2.57,-1.96,;-1.24,-2.73,;-1.24,-4.27,;-2.57,-5.04,;-3.91,-4.27,;-5.24,-5.04,;-3.91,-2.73,;-1.24,.35,;-5.24,2.66,;-6.57,1.89,;-5.24,4.2,;2.67,1.12,;3.58,-.12,;5.04,.35,;5.04,1.89,;3.58,2.37,;2.81,3.7,;3.58,5.04,;1.27,3.7,;2.04,5.04,;2.51,-3.5,;4,-3.89,)| Show InChI InChI=1S/C25H27ClF3N5O2/c1-14-4-6-15(7-5-14)13-34-22-18(32-24(34)33-8-2-3-20(33)25(27,28)29)10-19(23(35)36)31-21(22)16-9-17(26)12-30-11-16/h9-12,14-15,20H,2-8,13H2,1H3,(H,35,36)/t14-,15-,20-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi... |
US Patent US8962611 (2015)
BindingDB Entry DOI: 10.7270/Q28G8JDZ |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM135147
(US8846657, 3.39)Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)C(O)=O)N2CCC[C@H]2C(F)(F)F)CC1 |r,wU:4.4,wD:1.0,29.33,(6.57,-3.2,;5.09,-2.81,;4.69,-1.32,;3.2,-.92,;2.11,-2.01,;.62,-1.61,;.23,-.12,;1.13,1.12,;.23,2.37,;-1.24,1.89,;-2.57,2.66,;-3.91,1.89,;-3.91,.35,;-2.57,-.42,;-2.57,-1.96,;-1.24,-2.73,;-1.24,-4.27,;-2.57,-5.04,;-3.91,-4.27,;-5.24,-5.04,;-3.91,-2.73,;-1.24,.35,;-5.24,2.66,;-6.57,1.89,;-5.24,4.2,;2.67,1.12,;3.58,-.12,;5.04,.35,;5.04,1.89,;3.58,2.37,;2.81,3.7,;3.58,5.04,;1.27,3.7,;2.04,5.04,;2.51,-3.5,;4,-3.89,)| Show InChI InChI=1S/C25H27ClF3N5O2/c1-14-4-6-15(7-5-14)13-34-22-18(32-24(34)33-8-2-3-20(33)25(27,28)29)10-19(23(35)36)31-21(22)16-9-17(26)12-30-11-16/h9-12,14-15,20H,2-8,13H2,1H3,(H,35,36)/t14-,15-,20-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi... |
US Patent US8846657 (2014)
BindingDB Entry DOI: 10.7270/Q29C6W3K |
More data for this
Ligand-Target Pair | |
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