Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM135199'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135199 (US8846657, 3.92) Show SMILES CO[C@@H]1C[C@@H](CF)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1 |r,wU:26.29,2.1,wD:29.33,4.4,(7.66,-.13,;6.33,-.9,;4.99,-.13,;4.99,1.41,;3.53,1.88,;2.76,3.21,;3.53,4.55,;2.62,.64,;3.53,-.61,;1.08,.64,;.18,1.88,;-1.29,1.41,;-2.62,2.18,;-3.96,1.41,;-3.96,-.13,;-2.62,-.9,;-2.62,-2.44,;-1.29,-3.21,;-1.29,-4.75,;-2.62,-5.52,;-3.96,-4.75,;-5.29,-5.52,;-3.96,-3.21,;-1.29,-.13,;.18,-.61,;.18,-2.15,;1.51,-2.92,;2.84,-2.15,;4.18,-2.92,;4.18,-4.46,;5.51,-5.23,;2.84,-5.23,;1.51,-4.46,;-5.29,2.18,;-6.75,1.7,;-7.66,2.95,;-6.75,4.19,;-7.52,5.52,;-5.29,3.72,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8962611 (2015) BindingDB Entry DOI: 10.7270/Q28G8JDZ
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135199 (US8846657, 3.92) Show SMILES CO[C@@H]1C[C@@H](CF)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1 |r,wU:26.29,2.1,wD:29.33,4.4,(7.66,-.13,;6.33,-.9,;4.99,-.13,;4.99,1.41,;3.53,1.88,;2.76,3.21,;3.53,4.55,;2.62,.64,;3.53,-.61,;1.08,.64,;.18,1.88,;-1.29,1.41,;-2.62,2.18,;-3.96,1.41,;-3.96,-.13,;-2.62,-.9,;-2.62,-2.44,;-1.29,-3.21,;-1.29,-4.75,;-2.62,-5.52,;-3.96,-4.75,;-5.29,-5.52,;-3.96,-3.21,;-1.29,-.13,;.18,-.61,;.18,-2.15,;1.51,-2.92,;2.84,-2.15,;4.18,-2.92,;4.18,-4.46,;5.51,-5.23,;2.84,-5.23,;1.51,-4.46,;-5.29,2.18,;-6.75,1.7,;-7.66,2.95,;-6.75,4.19,;-7.52,5.52,;-5.29,3.72,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8846657 (2014) BindingDB Entry DOI: 10.7270/Q29C6W3K
					More data for this Ligand-Target Pair