Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM135319'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135319 (US8846657, 5.22) Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2[C@H](C)CN(C[C@H]2C)C(=O)N(C)C)CC1 |r,wU:4.4,29.33,wD:1.0,34.39,(5.58,-4.38,;4.09,-3.98,;3.69,-2.49,;2.21,-2.09,;1.12,-3.18,;-.37,-2.78,;-.77,-.61,;.14,.64,;-.77,1.88,;-2.23,1.41,;-3.57,2.18,;-4.9,1.41,;-4.9,-.13,;-3.57,-.9,;-3.57,-2.44,;-2.23,-3.21,;-2.23,-4.75,;-3.57,-5.52,;-4.9,-4.75,;-6.24,-5.52,;-4.9,-3.21,;-2.23,-.13,;-6.24,2.18,;-7.7,1.7,;-8.61,2.95,;-7.7,4.19,;-8.47,5.52,;-6.24,3.72,;1.68,.64,;2.45,-.7,;1.68,-2.03,;3.99,-.7,;4.76,.64,;3.99,1.97,;2.45,1.97,;1.68,3.3,;6.3,.64,;7.07,1.97,;7.07,-.7,;8.61,-.7,;7.07,-2.24,;1.51,-4.67,;3,-5.07,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8962611 (2015) BindingDB Entry DOI: 10.7270/Q28G8JDZ
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135319 (US8846657, 5.22) Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2[C@H](C)CN(C[C@H]2C)C(=O)N(C)C)CC1 |r,wU:4.4,29.33,wD:1.0,34.39,(5.58,-4.38,;4.09,-3.98,;3.69,-2.49,;2.21,-2.09,;1.12,-3.18,;-.37,-2.78,;-.77,-.61,;.14,.64,;-.77,1.88,;-2.23,1.41,;-3.57,2.18,;-4.9,1.41,;-4.9,-.13,;-3.57,-.9,;-3.57,-2.44,;-2.23,-3.21,;-2.23,-4.75,;-3.57,-5.52,;-4.9,-4.75,;-6.24,-5.52,;-4.9,-3.21,;-2.23,-.13,;-6.24,2.18,;-7.7,1.7,;-8.61,2.95,;-7.7,4.19,;-8.47,5.52,;-6.24,3.72,;1.68,.64,;2.45,-.7,;1.68,-2.03,;3.99,-.7,;4.76,.64,;3.99,1.97,;2.45,1.97,;1.68,3.3,;6.3,.64,;7.07,1.97,;7.07,-.7,;8.61,-.7,;7.07,-2.24,;1.51,-4.67,;3,-5.07,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8846657 (2014) BindingDB Entry DOI: 10.7270/Q29C6W3K
					More data for this Ligand-Target Pair