Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM135425'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135425 (US8846657, 16.1) Show SMILES CC([C@H]1CC[C@H](C)CC1)n1c(nc2cc(nc(-c3cncc(Cl)c3)c12)-c1noc(=O)[nH]1)N1CCN(C[C@H]1C)C(=O)C1(F)CC1 |r,wU:2.1,wD:5.5,36.42,(-1.36,-3.19,;-.27,-2.1,;1.22,-2.5,;2.31,-1.41,;3.8,-1.81,;4.19,-3.29,;5.68,-3.69,;3.11,-4.38,;1.62,-3.98,;-.67,-.61,;.24,.64,;-.67,1.88,;-2.13,1.41,;-3.47,2.18,;-4.8,1.41,;-4.8,-.13,;-3.47,-.9,;-3.47,-2.44,;-2.13,-3.21,;-2.13,-4.75,;-3.47,-5.52,;-4.8,-4.75,;-6.13,-5.52,;-4.8,-3.21,;-2.13,-.13,;-6.13,2.18,;-7.6,1.7,;-8.5,2.95,;-7.6,4.19,;-8.37,5.52,;-6.13,3.72,;1.78,.64,;2.55,-.7,;4.09,-.7,;4.86,.64,;4.09,1.97,;2.55,1.97,;1.78,3.3,;6.4,.64,;7.17,1.97,;7.17,-.7,;8.26,.39,;7.17,-2.24,;8.5,-1.47,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8962611 (2015) BindingDB Entry DOI: 10.7270/Q28G8JDZ
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135425 (US8846657, 16.1) Show SMILES CC([C@H]1CC[C@H](C)CC1)n1c(nc2cc(nc(-c3cncc(Cl)c3)c12)-c1noc(=O)[nH]1)N1CCN(C[C@H]1C)C(=O)C1(F)CC1 |r,wU:2.1,wD:5.5,36.42,(-1.36,-3.19,;-.27,-2.1,;1.22,-2.5,;2.31,-1.41,;3.8,-1.81,;4.19,-3.29,;5.68,-3.69,;3.11,-4.38,;1.62,-3.98,;-.67,-.61,;.24,.64,;-.67,1.88,;-2.13,1.41,;-3.47,2.18,;-4.8,1.41,;-4.8,-.13,;-3.47,-.9,;-3.47,-2.44,;-2.13,-3.21,;-2.13,-4.75,;-3.47,-5.52,;-4.8,-4.75,;-6.13,-5.52,;-4.8,-3.21,;-2.13,-.13,;-6.13,2.18,;-7.6,1.7,;-8.5,2.95,;-7.6,4.19,;-8.37,5.52,;-6.13,3.72,;1.78,.64,;2.55,-.7,;4.09,-.7,;4.86,.64,;4.09,1.97,;2.55,1.97,;1.78,3.3,;6.4,.64,;7.17,1.97,;7.17,-.7,;8.26,.39,;7.17,-2.24,;8.5,-1.47,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8846657 (2014) BindingDB Entry DOI: 10.7270/Q29C6W3K
					More data for this Ligand-Target Pair