Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM135438'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135438 (US8846657, 18.6) Show SMILES COc1ncc(Cl)cc1-c1nc(cc2nc(N3CCO[C@@H]4CCC[C@@H]34)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1 |r,wU:20.21,27.29,wD:24.24,30.33,(-5.64,-3.21,;-4.31,-2.44,;-2.98,-3.21,;-2.98,-4.75,;-1.64,-5.52,;-.31,-4.75,;1.02,-5.52,;-.31,-3.21,;-1.64,-2.44,;-1.64,-.9,;-2.98,-.13,;-2.98,1.41,;-1.64,2.18,;-.31,1.41,;1.16,1.88,;2.06,.64,;3.6,.64,;4.37,-.7,;5.91,-.7,;6.68,.64,;5.91,1.97,;6.39,3.43,;5.14,4.34,;3.89,3.43,;4.37,1.97,;1.16,-.61,;1.16,-2.15,;2.49,-2.92,;3.82,-2.15,;5.16,-2.92,;5.16,-4.46,;6.49,-5.23,;3.82,-5.23,;2.49,-4.46,;-.31,-.13,;-4.31,2.18,;-5.78,1.7,;-6.68,2.95,;-5.78,4.19,;-6.55,5.52,;-4.31,3.72,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8962611 (2015) BindingDB Entry DOI: 10.7270/Q28G8JDZ
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135438 (US8846657, 18.6) Show SMILES COc1ncc(Cl)cc1-c1nc(cc2nc(N3CCO[C@@H]4CCC[C@@H]34)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1 |r,wU:20.21,27.29,wD:24.24,30.33,(-5.64,-3.21,;-4.31,-2.44,;-2.98,-3.21,;-2.98,-4.75,;-1.64,-5.52,;-.31,-4.75,;1.02,-5.52,;-.31,-3.21,;-1.64,-2.44,;-1.64,-.9,;-2.98,-.13,;-2.98,1.41,;-1.64,2.18,;-.31,1.41,;1.16,1.88,;2.06,.64,;3.6,.64,;4.37,-.7,;5.91,-.7,;6.68,.64,;5.91,1.97,;6.39,3.43,;5.14,4.34,;3.89,3.43,;4.37,1.97,;1.16,-.61,;1.16,-2.15,;2.49,-2.92,;3.82,-2.15,;5.16,-2.92,;5.16,-4.46,;6.49,-5.23,;3.82,-5.23,;2.49,-4.46,;-.31,-.13,;-4.31,2.18,;-5.78,1.7,;-6.68,2.95,;-5.78,4.19,;-6.55,5.52,;-4.31,3.72,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8846657 (2014) BindingDB Entry DOI: 10.7270/Q29C6W3K
					More data for this Ligand-Target Pair