Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM135917'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM135917 (US8859586, 1) Show SMILES COc1cc2CC(=O)N(C3CCCCC3)C(c3ccc(Cl)cc3)c2cc1OC(C)C Show InChI InChI=1S/C25H30ClNO3/c1-16(2)30-23-15-21-18(13-22(23)29-3)14-24(28)27(20-7-5-4-6-8-20)25(21)17-9-11-19(26)12-10-17/h9-13,15-16,20,25H,4-8,14H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	894	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8859586 (2014) BindingDB Entry DOI: 10.7270/Q2RF5SR6
					More data for this Ligand-Target Pair