Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM143507'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM143507 (US8969341, 125) Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.187	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM143507 (US8969341, 125) Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair