Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM162064'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM162064 (US9051279, 77) Show SMILES COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(cc1)N(C)C[C@H]1CC[C@@H](CC1)NS(C)(=O)=O |r,wU:36.43,wD:9.9,33.36,(6.67,4.34,;6.67,2.8,;5.33,2.03,;4,2.8,;2.67,2.03,;1.33,2.8,;,2.03,;-1.33,2.8,;,.49,;1.33,-.28,;1.33,-1.82,;,-2.59,;,-4.13,;1.33,-4.9,;1.33,-6.44,;2.67,-4.13,;2.67,-2.59,;2.67,.49,;4,-.28,;5.33,.49,;6.67,-.28,;8,.49,;9.34,-.28,;8,2.03,;-1.33,-.28,;-1.33,-1.82,;-2.67,-2.59,;-4,-1.82,;-4,-.28,;-2.67,.49,;-5.33,-2.59,;-5.33,-4.13,;-6.67,-1.82,;-6.67,-.28,;-5.33,.49,;-5.33,2.03,;-6.67,2.8,;-8,2.03,;-8,.49,;-6.67,4.34,;-8,5.11,;-9.34,4.34,;-8.77,6.44,;-7.23,6.44,)| Show InChI InChI=1S/C34H42ClN3O5S/c1-22(2)43-32-20-30-25(18-31(32)42-4)19-33(39)38(34(30)24-8-10-26(35)11-9-24)29-16-14-28(15-17-29)37(3)21-23-6-12-27(13-7-23)36-44(5,40)41/h8-11,14-18,20,22-23,27,34,36H,6-7,12-13,19,21H2,1-5H3/t23-,27-,34-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair