Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM35067'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM35067 (N-acylpolyamine (NAPA) scaffold, 14) Show SMILES NCCCCC(CN(C(CCC(O)=O)CN(CCC(N)=O)C(=O)NCCCc1ccc(Br)cc1)C(=O)NCCc1ccc(Br)cc1)N(CC(CCC(O)=O)NC(N)=O)C(=O)NCCCc1ccccc1 Show InChI InChI=1S/C49H70Br2N10O9/c50-38-17-13-36(14-18-38)11-7-28-55-47(68)59(31-26-43(53)62)33-42(22-24-45(65)66)61(49(70)57-30-25-37-15-19-39(51)20-16-37)34-41(12-4-5-27-52)60(32-40(58-46(54)67)21-23-44(63)64)48(69)56-29-6-10-35-8-2-1-3-9-35/h1-3,8-9,13-20,40-42H,4-7,10-12,21-34,52H2,(H2,53,62)(H,55,68)(H,56,69)(H,57,70)(H,63,64)(H,65,66)(H3,54,58,67)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	7.6	23
NIH					Assay Description Inhibitory activities of NAPAs were measured by fluorescence anisotropy competition experiments. Protein was incubated with fluorescein-labeled huma...				Bioorg Med Chem 17: 7884-93 (2009) Article DOI: 10.1016/j.bmc.2009.10.032 BindingDB Entry DOI: 10.7270/Q2057D90
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