Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM427115'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427115 ((3R)-2-[(4-Chloro-2-methanesulfinylphenyl)methyl]-...) Show SMILES C[S@@](=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)C(C)(C)O |r| Show InChI InChI=1S/C30H30Cl2FNO5S/c1-28(2,37)20-12-23-26(24(33)13-20)30(19-5-8-21(31)9-6-19,39-17-29(16-35)10-11-29)34(27(23)36)15-18-4-7-22(32)14-25(18)40(3)38/h4-9,12-14,35,37H,10-11,15-17H2,1-3H3/t30-,40-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair