Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50012587'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50012587 (CHEMBL3260822) Show SMILES CC(C)(C)NC(=O)Cc1ccc(Cl)c(F)c1-n1c(nc(-c2nnc(N)o2)c1-c1ccc(F)c(Cl)c1)C1CCCCC1 |(2.75,-50.65,;4.05,-51.47,;4,-53.01,;2.71,-52.23,;5.42,-50.75,;5.47,-49.21,;4.17,-48.39,;6.83,-48.49,;8.14,-49.31,;8.08,-50.85,;9.39,-51.67,;10.75,-50.94,;12.06,-51.75,;10.8,-49.41,;12.16,-48.68,;9.5,-48.59,;9.56,-47.06,;10.83,-46.2,;10.41,-44.72,;8.87,-44.67,;8,-43.39,;6.46,-43.34,;6.04,-41.86,;7.31,-41,;7.36,-39.46,;8.53,-41.94,;8.35,-46.11,;6.81,-46.11,;6.04,-47.43,;4.5,-47.43,;3.73,-46.09,;2.19,-46.08,;4.51,-44.76,;3.75,-43.42,;6.05,-44.77,;12.28,-46.73,;12.54,-48.25,;13.99,-48.78,;15.17,-47.79,;14.9,-46.27,;13.45,-45.74,)| Show InChI InChI=1S/C29H30Cl2F2N6O2/c1-29(2,3)36-21(40)14-17-9-11-18(30)22(33)24(17)39-25(16-10-12-20(32)19(31)13-16)23(27-37-38-28(34)41-27)35-26(39)15-7-5-4-6-8-15/h9-13,15H,4-8,14H2,1-3H3,(H2,34,38)(H,36,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) (2 to 188) assessed as inhibition of p53-MDM2 interaction by TR-FRET assay				Bioorg Med Chem Lett 24: 2110-4 (2014) Article DOI: 10.1016/j.bmcl.2014.03.039 BindingDB Entry DOI: 10.7270/Q2RJ4M1C
					More data for this Ligand-Target Pair