Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50446204'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50446204 (CHEMBL3109055) Show SMILES COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1nc(Cl)ccc21)C(N)=O |r| Show InChI InChI=1S/C30H30Cl2FN5O4/c1-29(2,3)13-20-30(16-9-11-21(32)37-26(16)38-28(30)41)22(15-6-5-7-17(31)23(15)33)24(36-20)27(40)35-18-10-8-14(25(34)39)12-19(18)42-4/h5-12,20,22,24,36H,13H2,1-4H3,(H2,34,39)(H,35,40)(H,37,38,41)/t20-,22-,24+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Roche Pharma Research Curated by ChEMBL					Assay Description Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with biotinylated p53 after 1 hr by HTRF assay				ACS Med Chem Lett 5: 124-7 (2014) Article DOI: 10.1021/ml400359z BindingDB Entry DOI: 10.7270/Q20V8F7S
					More data for this Ligand-Target Pair