Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50500867'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50500867 (CHEMBL3800181) Show SMILES CCOc1ccc(cc1)-c1c(NC(=O)c2ccc(cc2)C(C)(C)C)c(nn1-c1ccc(Oc2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C35H33N3O5/c1-5-42-27-19-13-23(14-20-27)32-30(36-33(39)24-11-15-25(16-12-24)35(2,3)4)31(34(40)41)37-38(32)26-17-21-29(22-18-26)43-28-9-7-6-8-10-28/h6-22H,5H2,1-4H3,(H,36,39)(H,40,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	689	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University of Technology Curated by ChEMBL					Assay Description Displacement of FAM-p53TAD peptide from N-terminal 8x His-tagged human MDM2 (25 to 108 residues) expressed in Escherichia coli BL21 (DE3) after 30 mi...				J Med Chem 59: 3152-62 (2016) Article DOI: 10.1021/acs.jmedchem.5b01913 BindingDB Entry DOI: 10.7270/Q2S75KBK
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