Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 [1-118,T47W] (Homo sapiens (Human)) | BDBM207976 (N-Methyl-3,5-di(4-chlorobenzyl)-4-(6-chloro-1H-ind...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 500 | n/a | n/a | n/a | 7.4 | 25 |
Jagiellonian University | Assay Description MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W... | ACS Chem Biol 11: 3310-3318 (2016) Article DOI: 10.1021/acschembio.6b00596 BindingDB Entry DOI: 10.7270/Q2K35SH2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |