BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2 [1-188]' and Ligand = 'BDBM215385'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [1-188]


(Homo sapiens (Human))		BDBM215385
PNG
(US9296736, 366 | US9593129, Example 366)
Show SMILES CCC(CC)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C30H37Cl2NO5S/c1-4-24(5-2)39(37,38)18-26(19-9-10-19)33-28(20-11-13-22(31)14-12-20)25(21-7-6-8-23(32)15-21)16-30(3,29(33)36)17-27(34)35/h6-8,11-15,19,24-26,28H,4-5,9-10,16-18H2,1-3H3,(H,34,35)/t25-,26-,28-,30-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...

US Patent US9593129 (2017)


BindingDB Entry DOI: 10.7270/Q20P1232
More data for this
Ligand-Target Pair