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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2 [17-125]' and Ligand = 'BDBM326300'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [17-125]


(Homo sapiens (Human))		BDBM326300
PNG
(4-{[(1R)-1- cyclobutylethyl] amino}-6-(3- methylph...)
Show SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(OC(F)(F)F)cc3)c12)C(O)=O)C1CCC1 |r|
Show InChI InChI=1S/C28H27F3N4O3/c1-16-5-3-8-20(13-16)23-14-22-24(35(23)15-18-9-11-21(12-10-18)38-28(29,30)31)25(34-26(33-22)27(36)37)32-17(2)19-6-4-7-19/h3,5,8-14,17,19H,4,6-7,15H2,1-2H3,(H,36,37)(H,32,33,34)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 348n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...

US Patent US9637493 (2017)


BindingDB Entry DOI: 10.7270/Q28917Z1
More data for this
Ligand-Target Pair