Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha' and Ligand = 'BDBM50204471'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50204471 (CHEMBL3927498) Show SMILES OCc1ccc(s1)-c1nc(-c2ccccc2)c2ccccn12 Show InChI InChI=1S/C18H14N2OS/c21-12-14-9-10-16(22-14)18-19-17(13-6-2-1-3-7-13)15-8-4-5-11-20(15)18/h1-11,21H,12H2	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Institute of Innovative Research Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 5887-5890 (2016) Article DOI: 10.1016/j.bmcl.2016.11.009 BindingDB Entry DOI: 10.7270/Q2X350G6
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