Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM270580'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270580 ((R)-4-((8-chloro-6- (((S)-(4- fluorophenyl)(1-(1- ...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1(CC1)C(F)(F)F |r| Show InChI InChI=1S/C31H25ClF4N8/c32-24-16-22(15-23-28(24)38-18-39-29(23)41-25(7-4-14-37)19-5-2-1-3-6-19)40-27(20-8-10-21(33)11-9-20)26-17-44(43-42-26)30(12-13-30)31(34,35)36/h1-3,5-6,8-11,15-18,25,27,40H,4,7,12-13H2,(H,38,39,41)/t25-,27?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270580 ((R)-4-((8-chloro-6- (((S)-(4- fluorophenyl)(1-(1- ...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1(CC1)C(F)(F)F |r| Show InChI InChI=1S/C31H25ClF4N8/c32-24-16-22(15-23-28(24)38-18-39-29(23)41-25(7-4-14-37)19-5-2-1-3-6-19)40-27(20-8-10-21(33)11-9-20)26-17-44(43-42-26)30(12-13-30)31(34,35)36/h1-3,5-6,8-11,15-18,25,27,40H,4,7,12-13H2,(H,38,39,41)/t25-,27?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270580 ((R)-4-((8-chloro-6- (((S)-(4- fluorophenyl)(1-(1- ...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1(CC1)C(F)(F)F |r| Show InChI InChI=1S/C31H25ClF4N8/c32-24-16-22(15-23-28(24)38-18-39-29(23)41-25(7-4-14-37)19-5-2-1-3-6-19)40-27(20-8-10-21(33)11-9-20)26-17-44(43-42-26)30(12-13-30)31(34,35)36/h1-3,5-6,8-11,15-18,25,27,40H,4,7,12-13H2,(H,38,39,41)/t25-,27?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270580 ((R)-4-((8-chloro-6- (((S)-(4- fluorophenyl)(1-(1- ...) Show SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1(CC1)C(F)(F)F |r| Show InChI InChI=1S/C31H25ClF4N8/c32-24-16-22(15-23-28(24)38-18-39-29(23)41-25(7-4-14-37)19-5-2-1-3-6-19)40-27(20-8-10-21(33)11-9-20)26-17-44(43-42-26)30(12-13-30)31(34,35)36/h1-3,5-6,8-11,15-18,25,27,40H,4,7,12-13H2,(H,38,39,41)/t25-,27?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair