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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM4911'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4911
PNG
((3Z)-6-(2-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-...)
Show SMILES COc1ccccc1-c1ccc2\C(=C\c3cc4CCCCc4[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C24H22N2O2/c1-28-23-9-5-3-7-18(23)15-10-11-19-20(24(27)26-22(19)13-15)14-17-12-16-6-2-4-8-21(16)25-17/h3,5,7,9-14,25H,2,4,6,8H2,1H3,(H,26,27)/b20-14-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 43: 2655-63 (2000)


Article DOI: 10.1074/jbc.M512374200
BindingDB Entry DOI: 10.7270/Q2W66J0N
More data for this
Ligand-Target Pair