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Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [1-18,20-745,747-749,751-1210]' and Ligand = 'BDBM494929'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210]


(Homo sapiens (Human))		BDBM494929
PNG
(2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-((1-isopropyl-...)
Show SMILES COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(COCCN4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)nc3cn2)n1
Show InChI InChI=1S/C39H47N11O6/c1-24(2)49-31-21-33(43-32-8-11-40-39(44-32)48-12-9-26(55-3)10-13-48)41-22-29(31)42-34(49)23-56-19-18-46-14-16-47(17-15-46)25-4-5-27-28(20-25)38(54)50(37(27)53)30-6-7-35(51)45-36(30)52/h4-5,8,11,20-22,24,26,30H,6-7,9-10,12-19,23H2,1-3H3,(H,45,51,52)(H,40,41,43,44)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.; YALE UNIVERSITY

US Patent


Assay Description
All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...

US Patent US10994015 (2021)


BindingDB Entry DOI: 10.7270/Q2NS0Z1G
More data for this
Ligand-Target Pair