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Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [1-18,20-745,747-749,751-1210]' and Ligand = 'BDBM495011'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210]


(Homo sapiens (Human))		BDBM495011
PNG
(2-(7-((4-(3-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3...)
Show SMILES Oc1ccc(F)cc1C(N1Cc2cccc(NCCCCOCCCN3CCC(CC3)N3CCN(CC3)c3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)c2C1=O)C(=O)Nc1nccs1
Show InChI InChI=1S/C48H54FN9O8S/c49-31-7-11-39(59)36(27-31)42(44(62)53-48-51-16-26-67-48)57-29-30-5-3-6-37(41(30)47(57)65)50-15-1-2-24-66-25-4-17-54-18-13-32(14-19-54)55-20-22-56(23-21-55)33-8-9-34-35(28-33)46(64)58(45(34)63)38-10-12-40(60)52-43(38)61/h3,5-9,11,16,26-28,32,38,42,50,59H,1-2,4,10,12-15,17-25,29H2,(H,51,53,62)(H,52,60,61)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.80E+3n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.; YALE UNIVERSITY

US Patent


Assay Description
All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...

US Patent US10994015 (2021)


BindingDB Entry DOI: 10.7270/Q2NS0Z1G
More data for this
Ligand-Target Pair