Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [668-1210,T790M,L858R]' and Ligand = 'BDBM287607'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human))	BDBM287607 (N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...) Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc2ccc(-c3cnn(C)c3)n2n1 Show InChI InChI=1S/C27H33N9O2/c1-6-26(37)30-21-13-22(25(38-5)14-24(21)35-11-9-19(10-12-35)33(2)3)31-27-28-16-20-7-8-23(36(20)32-27)18-15-29-34(4)17-18/h6-8,13-17,19H,1,9-12H2,2-5H3,(H,30,37)(H,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent					Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...				US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG
					More data for this Ligand-Target Pair