Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [668-1210,T790M,L858R]' and Ligand = 'BDBM287619'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human))	BDBM287619 (N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...) Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(NC(=O)C=C)cc1Nc1ncc2ccc(C)n2n1 Show InChI InChI=1S/C24H31N7O2/c1-6-23(32)26-19-13-20(27-24-25-15-18-8-7-16(2)31(18)28-24)22(33-5)14-21(19)30-11-9-17(10-12-30)29(3)4/h6-8,13-15,17H,1,9-12H2,2-5H3,(H,26,32)(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent					Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...				US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG
					More data for this Ligand-Target Pair