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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [L858R,T790M,C797S]' and Ligand = 'BDBM494936'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor [L858R,T790M,C797S]


(Homo sapiens (Human))		BDBM494936
PNG
(2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-(1-(4-((1-isop...)
Show SMILES COC1(CCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1
Show InChI InChI=1S/C39H47N11O5/c1-24(2)49-25(3)42-29-23-41-33(22-31(29)49)43-32-9-13-40-38(44-32)48-15-11-39(55-4,12-16-48)10-14-46-17-19-47(20-18-46)26-5-6-27-28(21-26)37(54)50(36(27)53)30-7-8-34(51)45-35(30)52/h5-6,9,13,21-24,30H,7-8,10-12,14-20H2,1-4H3,(H,45,51,52)(H,40,41,43,44)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.; YALE UNIVERSITY

US Patent


Assay Description
All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...

US Patent US10994015 (2021)


BindingDB Entry DOI: 10.7270/Q2NS0Z1G
More data for this
Ligand-Target Pair