Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [T790M,L858R]' and Ligand = 'BDBM380788'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM380788 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nc(-c2cccnc2)c2cc[nH]c2n1 Show InChI InChI=1S/C26H30N8O2/c1-6-23(35)29-19-14-20(22(36-5)15-21(19)34(4)13-12-33(2)3)30-26-31-24(17-8-7-10-27-16-17)18-9-11-28-25(18)32-26/h6-11,14-16H,1,12-13H2,2-5H3,(H,29,35)(H2,28,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College					Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...				J Med Chem 51: 1706-18 (2008) BindingDB Entry DOI: 10.7270/Q2PV6NPJ
					More data for this Ligand-Target Pair