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Found 1 hit Enz. Inhib. hit(s) with Target = 'Estradiol 17-beta-dehydrogenase 2' and Ligand = 'BDBM50515431'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Estradiol 17-beta-dehydrogenase 2


(Mus musculus)		BDBM50515431
PNG
(CHEMBL4441357)
Show SMILES Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccc(NS(=O)(=O)c3ccc(cc3)C#N)cc2)c1F
Show InChI InChI=1S/C24H13F3N2O4S2/c25-18-11-17(21(26)24(31)22(18)27)23(30)20-10-9-19(34-20)14-3-5-15(6-4-14)29-35(32,33)16-7-1-13(12-28)2-8-16/h1-11,29,31H
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



ElexoPharm GmbH

Curated by ChEMBL


Assay Description
Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis

J Med Chem 62: 7289-7301 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00932
BindingDB Entry DOI: 10.7270/Q27H1NX9
More data for this
Ligand-Target Pair