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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-I' and Ligand = 'BDBM50239863'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic initiation factor 4A-I


(Homo sapiens (Human))		BDBM50239863
PNG
(CHEMBL4087449)
Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F
Show InChI InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda California Inc.

Curated by ChEMBL


Assay Description
Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...

J Med Chem 60: 5759-5771 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00461
BindingDB Entry DOI: 10.7270/Q2MC925G
More data for this
Ligand-Target Pair