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Found 1 hit Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-III' and Ligand = 'BDBM50239861'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50239861
PNG
(CHEMBL4092701)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18|
Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20E+4n/an/an/an/an/an/a



Takeda California Inc.

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

J Med Chem 60: 5759-5771 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00461
BindingDB Entry DOI: 10.7270/Q2MC925G
More data for this
Ligand-Target Pair