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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Extracellular calcium-sensing receptor' and Ligand = 'BDBM50325503'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50325503
PNG
(2-(4-bromo-2-(4-isopropylphenyl)-7-methoxy-1H-benz...)
Show SMILES COc1ccc(Br)c2nc(-c3ccc(cc3)C(C)C)n(CCN(C)C)c12
Show InChI InChI=1S/C21H26BrN3O/c1-14(2)15-6-8-16(9-7-15)21-23-19-17(22)10-11-18(26-5)20(19)25(21)13-12-24(3)4/h6-11,14H,12-13H2,1-5H3
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n/an/a 190n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilization

Bioorg Med Chem Lett 20: 5161-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.016
BindingDB Entry DOI: 10.7270/Q2H70G1X
More data for this
Ligand-Target Pair