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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Extracellular calcium-sensing receptor' and Ligand = 'BDBM50432968'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50432968
PNG
(CHEMBL2377748)
Show SMILES CS(=O)(=O)Nc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H35N5O4S2/c1-41(37,38)33-25-12-13-27-28(22-25)40-29(31-27)32-30(36)35(17-16-34-18-20-39-21-19-34)15-14-26(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-13,22,26,33H,14-21H2,1H3,(H,31,32,36)
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Article
PubMed
n/an/an/an/a 30n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...

Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
BindingDB Entry DOI: 10.7270/Q228090Q
More data for this
Ligand-Target Pair