BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Fatty-acid amide hydrolase 1' and Ligand = 'BDBM60622'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of recombinant FAAH expressed in Cos7 cells after 30 mins by using anandamide as a substrate by LC-MS method				Nat Chem Biol 5: 37-44 (2008) Article DOI: 10.1038/nchembio.129 BindingDB Entry DOI: 10.7270/Q2DN4582
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Louvain Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human FAAH				J Med Chem 52: 7410-20 (2009) Article DOI: 10.1021/jm900461w BindingDB Entry DOI: 10.7270/Q2TM7B59
Louvain Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Mus musculus (mouse))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of FAAH in C57B1/6J mouse brain membrane after 20 mins by using oleamide as a substrate by LC-MS method				Nat Chem Biol 5: 37-44 (2008) Article DOI: 10.1038/nchembio.129 BindingDB Entry DOI: 10.7270/Q2DN4582
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of FAAH				Nat Chem Biol 5: 8-9 (2008) Article DOI: 10.1038/nchembio0109-8 BindingDB Entry DOI: 10.7270/Q24M94R0
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Mus musculus (mouse))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of FAAH in mouse brain membrane using oleamide as substrate preincubated for 30 mins				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Mus musculus (mouse))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of FAAH in mouse brain membrane				J Med Chem 53: 1830-42 (2010) Article DOI: 10.1021/jm9016976 BindingDB Entry DOI: 10.7270/Q2KH0NFR
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of FAAH				Bioorg Med Chem 20: 6260-75 (2012) Article DOI: 10.1016/j.bmc.2012.09.011 BindingDB Entry DOI: 10.7270/Q2W37XDX
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Mus musculus (mouse))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	37
The Scripps Research Institute; Abide Therapeutics, Inc. US Patent					Assay Description Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...				US Patent US9133148 (2015) BindingDB Entry DOI: 10.7270/Q2TT4PR0
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Mus musculus (mouse))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Siena Curated by ChEMBL					Assay Description Inhibition of FAAH in mouse brain membrane using [13C]oleamide as substrate by LC-MS analysis				J Med Chem 59: 2612-32 (2016) Article DOI: 10.1021/acs.jmedchem.5b01812 BindingDB Entry DOI: 10.7270/Q21R6SC7
University of Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States. Curated by ChEMBL					Assay Description Inhibition of recombinant human FAAH using fluorogenic arachidonoyl-AMC as substrate preincubated for 30 mins followed by substrate addition measured...				J Med Chem 61: 3008-3026 (2018) Article DOI: 10.1021/acs.jmedchem.8b00070 BindingDB Entry DOI: 10.7270/Q2S46VD4
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM60622 (BDBM50300355 \| US11753371, Compound JZL-184 \| US91...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...				Bioorg Med Chem 20: 6260-75 (2012) Article DOI: 10.1016/j.bmc.2012.09.011 BindingDB Entry DOI: 10.7270/Q2W37XDX
Sapienza Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair