BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 2' and Ligand = 'BDBM161389'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
Taiho Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020) BindingDB Entry DOI: 10.7270/Q23N26F5
Taiho Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.5	25
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US9108973 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HJV
Taiho Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021) BindingDB Entry DOI: 10.7270/Q2319ZZF
Taiho Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00174 BindingDB Entry DOI: 10.7270/Q2P84GS6
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021) BindingDB Entry DOI: 10.7270/Q2319ZZF
Taiho Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161389 (US10124003, Ref. Ex. Compound 3 \| US10835536, Ex. ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
Taiho Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)