Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM102540' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102540
(US8536175, 144)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(8.07,3.99,;8.84,2.66,;8.07,1.32,;8.84,-.01,;8.07,-1.34,;8.84,-2.68,;10.38,-2.68,;6.53,-1.34,;5.76,-2.68,;5.76,-.01,;6.53,1.32,;5.76,2.66,;4.22,-.01,;3.45,1.32,;1.91,1.32,;1.14,-.01,;-.4,-.01,;-1.17,1.32,;-1.17,-1.34,;-2.71,-1.34,;-3.48,-.01,;-5.02,-.01,;-5.79,-1.34,;-7.33,-1.34,;-8.1,-.01,;-9.64,-.01,;-10.41,1.32,;-9.64,2.66,;-10.41,3.99,;-8.1,2.66,;-7.33,1.32,;-5.02,-2.68,;-3.48,-2.68,;1.91,-1.34,;1.14,-2.68,;1.91,-4.01,;3.45,-4.01,;4.22,-2.68,;3.45,-1.34,)| Show InChI InChI=1S/C28H28ClFN6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102540
(US8536175, 144)Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2nccnc12 |(8.07,3.99,;8.84,2.66,;8.07,1.32,;8.84,-.01,;8.07,-1.34,;8.84,-2.68,;10.38,-2.68,;6.53,-1.34,;5.76,-2.68,;5.76,-.01,;6.53,1.32,;5.76,2.66,;4.22,-.01,;3.45,1.32,;1.91,1.32,;1.14,-.01,;-.4,-.01,;-1.17,1.32,;-1.17,-1.34,;-2.71,-1.34,;-3.48,-.01,;-5.02,-.01,;-5.79,-1.34,;-7.33,-1.34,;-8.1,-.01,;-9.64,-.01,;-10.41,1.32,;-9.64,2.66,;-10.41,3.99,;-8.1,2.66,;-7.33,1.32,;-5.02,-2.68,;-3.48,-2.68,;1.91,-1.34,;1.14,-2.68,;1.91,-4.01,;3.45,-4.01,;4.22,-2.68,;3.45,-1.34,)| Show InChI InChI=1S/C28H28ClFN6O3/c1-35-10-12-36(13-11-35)16-17-4-7-22(33-15-17)34-28(37)19-6-5-18(26-27(19)32-9-8-31-26)23-24(29)20(38-2)14-21(39-3)25(23)30/h4-9,14-15H,10-13,16H2,1-3H3,(H,33,34,37) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Protein kinase activity measured by the microfluidic caliper method. |
US Patent US8536175 (2013)
BindingDB Entry DOI: 10.7270/Q27D2SSH |
More data for this Ligand-Target Pair | |