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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4' and Ligand = 'BDBM209292'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM209292
PNG
(US9266883, 50)
Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@H]4CCOC4)c(cn3)C#N)c2nc1C=O |r|
Show InChI InChI=1S/C21H21N5O5/c22-8-15-9-23-19(7-18(15)31-16-3-5-30-12-16)25-21(29)26-4-1-2-13-6-14(10-27)17(11-28)24-20(13)26/h6-7,9,11,16,27H,1-5,10,12H2,(H,23,25,29)/t16-/m0/s1
PDB

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UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Mus musculus)
BDBM209292
PNG
(US9266883, 50)
Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@H]4CCOC4)c(cn3)C#N)c2nc1C=O |r|
Show InChI InChI=1S/C21H21N5O5/c22-8-15-9-23-19(7-18(15)31-16-3-5-30-12-16)25-21(29)26-4-1-2-13-6-14(10-27)17(11-28)24-20(13)26/h6-7,9,11,16,27H,1-5,10,12H2,(H,23,25,29)/t16-/m0/s1
PDB

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UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Mus musculus)
BDBM209292
PNG
(US9266883, 50)
Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@H]4CCOC4)c(cn3)C#N)c2nc1C=O |r|
Show InChI InChI=1S/C21H21N5O5/c22-8-15-9-23-19(7-18(15)31-16-3-5-30-12-16)25-21(29)26-4-1-2-13-6-14(10-27)17(11-28)24-20(13)26/h6-7,9,11,16,27H,1-5,10,12H2,(H,23,25,29)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 36n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ
More data for this
Ligand-Target Pair