BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4' and Ligand = 'BDBM209384'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM209384
PNG
(US9266883, 257)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(-c4ccnn4C)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H24N8O3/c1-30-20(5-6-27-30)17-10-15-4-3-8-31(22(15)28-19(17)14-32)23(33)29-21-11-18(25-7-9-34-2)16(12-24)13-26-21/h5-6,10-11,13-14H,3-4,7-9H2,1-2H3,(H2,25,26,29,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Mus musculus)
BDBM209384
PNG
(US9266883, 257)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(-c4ccnn4C)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H24N8O3/c1-30-20(5-6-27-30)17-10-15-4-3-8-31(22(15)28-19(17)14-32)23(33)29-21-11-18(25-7-9-34-2)16(12-24)13-26-21/h5-6,10-11,13-14H,3-4,7-9H2,1-2H3,(H2,25,26,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ
More data for this
Ligand-Target Pair