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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4' and Ligand = 'BDBM443223'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443223
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-17-32(18-42)10-12-41(7-2)13-11-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)


BindingDB Entry DOI: 10.7270/Q2Z322RS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443223
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-17-32(18-42)10-12-41(7-2)13-11-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Zhejiang Hisun Pharmaceutical Co., Ltd.

US Patent


Assay Description
The experimental procedure is briefly described as follows: the test compound was first dissolved in DMSO to prepare a stock solution, and then gradi...


US Patent US10654836 (2020)


BindingDB Entry DOI: 10.7270/Q25M68RT
More data for this
Ligand-Target Pair