Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4' and Ligand = 'BDBM50465111'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50465111 (CHEMBL4279514) Show SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(cc2OCC(C)C)N2CCC(CC2)N(C)C)ncc1C#N)C(N)=O |r,c:5| Show InChI InChI=1S/C30H40N8O2/c1-18(2)17-40-25-14-23(38-11-9-22(10-12-38)37(3)4)7-8-24(25)34-30-33-16-21(15-31)29(36-30)35-27-20-6-5-19(13-20)26(27)28(32)39/h5-8,14,16,18-20,22,26-27H,9-13,17H2,1-4H3,(H2,32,39)(H2,33,34,35,36)/t19-,20+,26+,27-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50465111 (CHEMBL4279514) Show SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(cc2OCC(C)C)N2CCC(CC2)N(C)C)ncc1C#N)C(N)=O |r,c:5| Show InChI InChI=1S/C30H40N8O2/c1-18(2)17-40-25-14-23(38-11-9-22(10-12-38)37(3)4)7-8-24(25)34-30-33-16-21(15-31)29(36-30)35-27-20-6-5-19(13-20)26(27)28(32)39/h5-8,14,16,18-20,22,26-27H,9-13,17H2,1-4H3,(H2,32,39)(H2,33,34,35,36)/t19-,20+,26+,27-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...				ACS Med Chem Lett 9: 215-220 (2018) Article DOI: 10.1021/acsmedchemlett.7b00485 BindingDB Entry DOI: 10.7270/Q27947C7
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50465111 (CHEMBL4279514) Show SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(cc2OCC(C)C)N2CCC(CC2)N(C)C)ncc1C#N)C(N)=O |r,c:5| Show InChI InChI=1S/C30H40N8O2/c1-18(2)17-40-25-14-23(38-11-9-22(10-12-38)37(3)4)7-8-24(25)34-30-33-16-21(15-31)29(36-30)35-27-20-6-5-19(13-20)26(27)28(32)39/h5-8,14,16,18-20,22,26-27H,9-13,17H2,1-4H3,(H2,32,39)(H2,33,34,35,36)/t19-,20+,26+,27-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of TEL-fused FGFR4 cytoplasmic/juxta membrane domain (unknown origin) expressed in mouse Ba/F3 cells assessed as reduction in FGFR4 autoph...				ACS Med Chem Lett 9: 215-220 (2018) Article DOI: 10.1021/acsmedchemlett.7b00485 BindingDB Entry DOI: 10.7270/Q27947C7
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Mus musculus)	BDBM50465111 (CHEMBL4279514) Show SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(cc2OCC(C)C)N2CCC(CC2)N(C)C)ncc1C#N)C(N)=O |r,c:5| Show InChI InChI=1S/C30H40N8O2/c1-18(2)17-40-25-14-23(38-11-9-22(10-12-38)37(3)4)7-8-24(25)34-30-33-16-21(15-31)29(36-30)35-27-20-6-5-19(13-20)26(27)28(32)39/h5-8,14,16,18-20,22,26-27H,9-13,17H2,1-4H3,(H2,32,39)(H2,33,34,35,36)/t19-,20+,26+,27-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01019 BindingDB Entry DOI: 10.7270/Q2FB56MJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50465111 (CHEMBL4279514) Show SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(cc2OCC(C)C)N2CCC(CC2)N(C)C)ncc1C#N)C(N)=O |r,c:5| Show InChI InChI=1S/C30H40N8O2/c1-18(2)17-40-25-14-23(38-11-9-22(10-12-38)37(3)4)7-8-24(25)34-30-33-16-21(15-31)29(36-30)35-27-20-6-5-19(13-20)26(27)28(32)39/h5-8,14,16,18-20,22,26-27H,9-13,17H2,1-4H3,(H2,32,39)(H2,33,34,35,36)/t19-,20+,26+,27-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Displacement of PRO-128 from recombinant human N-terminal GST/His6-tagged FGFR4 (391 to 802 residues) expressed in baculovirus infected Sf9 insect ce...				ACS Med Chem Lett 9: 215-220 (2018) Article DOI: 10.1021/acsmedchemlett.7b00485 BindingDB Entry DOI: 10.7270/Q27947C7
					More data for this Ligand-Target Pair