BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Free fatty acid receptor 2' and Ligand = 'BDBM50450263'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Free fatty acid receptor 2 (Homo sapiens (Human))	BDBM50450263 (CHEMBL4176503) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	204	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry				J Med Chem 61: 9534-9550 (2018) Article DOI: 10.1021/acs.jmedchem.8b00855 BindingDB Entry DOI: 10.7270/Q28S4SFW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 2 (Homo sapiens (Human))	BDBM50450263 (CHEMBL4176503) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	794	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay				J Med Chem 61: 9534-9550 (2018) Article DOI: 10.1021/acs.jmedchem.8b00855 BindingDB Entry DOI: 10.7270/Q28S4SFW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 2 (Mus musculus)	BDBM50450263 (CHEMBL4176503) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production				J Med Chem 61: 9534-9550 (2018) Article DOI: 10.1021/acs.jmedchem.8b00855 BindingDB Entry DOI: 10.7270/Q28S4SFW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 2 (Homo sapiens (Human))	BDBM50450263 (CHEMBL4176503) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	78	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRE...				J Med Chem 61: 9534-9550 (2018) Article DOI: 10.1021/acs.jmedchem.8b00855 BindingDB Entry DOI: 10.7270/Q28S4SFW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 2 (Mus musculus)	BDBM50450263 (CHEMBL4176503) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	363	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRE...				J Med Chem 61: 9534-9550 (2018) Article DOI: 10.1021/acs.jmedchem.8b00855 BindingDB Entry DOI: 10.7270/Q28S4SFW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)