BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'GABA-A receptor; alpha-5/beta-3/gamma-2' and Ligand = 'BDBM50179998'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
GABA-A receptor; alpha-5/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50179998 (7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Sussex Curated by ChEMBL					Assay Description Displacement of [3H]-flumazenil from human GABAA alpha5beta3gamma2 expressed in Ltk cells				J Med Chem 63: 3425-3446 (2020) Article DOI: 10.1021/acs.jmedchem.9b01312 BindingDB Entry DOI: 10.7270/Q2VD72WN
University of Sussex Curated by ChEMBL					More data for this Ligand-Target Pair
GABA-A receptor; alpha-5/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50179998 (7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp Laboratory Curated by ChEMBL					Assay Description Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cells				J Med Chem 49: 35-8 (2006) Article DOI: 10.1021/jm051065l BindingDB Entry DOI: 10.7270/Q21R6RBC
Merck Sharp Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair